We take road trips through Tallahassee, Florida's Big Bend, and South Georgia every few weeks to check out the Goodwill stores. There are 23 Goodwill & Goodcents stores in the area. I think Tallahassee's are the best, but a nice drive along the coast or up into rural Georgia is always relaxing.
Here is a short review/guide:
http://www.associatedcontent.com/article/7852866/a_guide_to_goodwill_thrift_stores_of.html?cat=46